Gene

Zfp217

Species
Mus musculus
Symbol
Zfp217
Name
zinc finger protein 217
Synonyms
  • 4933431C08Rik
  • AW987152
Biotype
protein coding gene
Automated Description
Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to act upstream of or within cellular senescence. Predicted to be located in mitochondrion and nuclear speck. Predicted to be part of histone deacetylase complex. Predicted to be active in nucleus. Is expressed in central nervous system; genitourinary system; paraxial mesenchyme; and tail. Orthologous to human ZNF217 (zinc finger protein 217).
MGI Description
PHENOTYPE: Knock-out mice show prenatal lethality. Heterozygotes are resistant to high-fat diet-induced obesity, have smaller adipocytes, improved glucose tolerance and insulin sensitivity, and increased energy expenditure on this diet. [provided by MGI curators]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR45925
No data available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

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Other Sources
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Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
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      Alleles and Variants

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      Variant type
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        Transgenic Alleles

        Species
        (carrying the transgene)
        Allele symbol
        Transgenic construct
        Expressed components
        Knock-down targets
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          Models

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            Sequence Feature Viewer

            Genome location
            Assembly version
            GRCm39
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            169.955M169.960M169.965M169.970M169.975M169.980M169.985M169.990M

            Sequence Details

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            Expression

            Primary Sources
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            Zfp217 molecule type
            Interactor gene
            Interactor species
            Interactor molecule type
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              Genetic Interactions

              Zfp217 role
              Zfp217 genetic perturbation
              Interactor gene
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