Gene

Card9

Species
Mus musculus
Symbol
Card9
Name
caspase recruitment domain family, member 9
Synonyms
  • gene model 782, (NCBI)
  • Gm782
Biotype
protein coding gene
Automated Description
Enables CARD domain binding activity. Involved in several processes, including antifungal innate immune response; positive regulation of MAPK cascade; and regulation of gene expression. Acts upstream of or within several processes, including positive regulation of JNK cascade; regulation of cytokine production; and response to bacterium. Part of CBM complex. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to human CARD9 (caspase recruitment domain family member 9).
MGI Description
PHENOTYPE: Mice homozygous for one allele of this gene display impaired immune responses to fungal infection but normal rates of bacterial clearance. However, homozygotes for a second allele display impaired bacterial clearance and impaired early innate immune responses. [provided by MGI curators]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR14559
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
GRCm39
Viewer Help
26.243M26.244M26.245M26.246M26.247M26.248M26.249M26.250M

Sequence Details

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Expression

Primary Sources
None
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions