Involved in spermatid development. Acts upstream of or within acrosome assembly; centrosome cycle; and cilium assembly. Located in several cellular components, including microtubule cytoskeleton; sperm head-tail coupling apparatus; and sperm principal piece. Orthologous to human CCDC42 (coiled-coil domain containing 42).
MGI Description
PHENOTYPE: Mice homozygous for a knock-out allele are viable and developmentally normal with no overt behavioral deficits. Males exhibit defects in the number and location of the sperm head-tail coupling apparatus, lack flagellated sperm, and are sterile.
[provided by MGI curators]