Enables aspartic endopeptidase activity, intramembrane cleaving and molecular adaptor activity. Involved in several processes, including acrosome assembly; fusion of sperm to egg plasma membrane involved in single fertilization; and protein stabilization. Located in endoplasmic reticulum membrane. Orthologous to human SPPL2C (signal peptide peptidase like 2C).
MGI Description
PHENOTYPE: Mice homozygous for a knock-out allele exhibit decreased testis weight, decreased number of elongated spermatids, asthenozoospermia, and decreased litter size in matings of male and female homozygotes. [provided by MGI curators]