Gene

Sppl2c

Species
Mus musculus
Symbol
Sppl2c
Name
signal peptide peptidase 2C
Synonyms
  • 4933407P14Rik
  • Imp5
Biotype
protein coding gene
Automated Description
Enables aspartic endopeptidase activity, intramembrane cleaving and molecular adaptor activity. Involved in several processes, including acrosome assembly; fusion of sperm to egg plasma membrane involved in single fertilization; and protein stabilization. Located in endoplasmic reticulum membrane. Orthologous to human SPPL2C (signal peptide peptidase like 2C).
MGI Description
PHENOTYPE: Mice homozygous for a knock-out allele exhibit decreased testis weight, decreased number of elongated spermatids, asthenozoospermia, and decreased litter size in matings of male and female homozygotes. [provided by MGI curators]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR12174
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
GRCm39
Viewer Help
104.0775M104.0780M104.0785M104.0790M104.0795M104.0800M104.0805M104.0810M104.0815M

Sequence Details

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Expression

Primary Sources
None
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions