Version: 8.0.0
Date: Tue Jan 28 2025
Ppp1r13l
Mus musculusMGI:3525053
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

Ppp1r13l

Species
Mus musculus
Symbol
Ppp1r13l
Name
protein phosphatase 1, regulatory subunit 13 like
Synonyms
  • AV260376
  • expressed sequence AV260376
Biotype
protein coding gene
Automated Description
Predicted to enable identical protein binding activity. Involved in negative regulation of inflammatory response. Acts upstream of or within several processes, including cardiac muscle contraction; heart development; and negative regulation of transcription by RNA polymerase II. Predicted to be located in cell junction; cytosol; and intercellular bridge. Is expressed in esophagus; sensory organ; submandibular gland primordium; and vibrissa. Used to study arrhythmogenic right ventricular cardiomyopathy. Orthologous to human PPP1R13L (protein phosphatase 1 regulatory subunit 13 like).
MGI Description
PHENOTYPE: Homozygotes for spontaneous mutations in this gene exhibit cardiovascular defects leading to cardiomyopathy, open eyelids at birth, and coat abnormalities. One allele also shows postnatal lethality dependent on strain background and decreased weight, while another shows impaired fertility. [provided by MGI curators]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR24164
No data available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
Phenotype Term
Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    Gene
    Association
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      Alleles and Variants

      Allele/Variant Symbol
      Allele Synonyms
      Category
      Variant
      Variant type
      Molecular consequence
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        Transgenic Alleles

        Species
        (carrying the transgene)
        Allele symbol
        Transgenic construct
        Expressed components
        Knock-down targets
        Regulatory regions
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          Models

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            Sequence Feature Viewer

            Genome location
            Assembly version
            GRCm39
            Viewer Help
            19.094M19.096M19.098M19.100M19.102M19.104M19.106M19.108M19.110M19.112M

            Sequence Details

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            Expression

            Primary Sources
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            Ppp1r13l molecule type
            Interactor gene
            Interactor species
            Interactor molecule type
            Detection methods
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              Genetic Interactions

              Ppp1r13l role
              Ppp1r13l genetic perturbation
              Interactor gene
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              Interactor role
              Interactor genetic perturbation
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