Predicted to be involved in microtubule cytoskeleton organization and regulation of mitotic nuclear division. Predicted to be located in several cellular components, including centrosome; cytosol; and nucleoplasm. Predicted to be part of 3M complex. Human ortholog(s) of this gene implicated in 3-M syndrome. Orthologous to human CCDC8 (coiled-coil domain containing 8).
MGI Description
PHENOTYPE: Mice homozygous for a knock-out allele exhibit perinatal lethality, intrauterine growth restriction, and placental defects. [provided by MGI curators]