Gene

Rpl10l

Species
Mus musculus
Symbol
Rpl10l
Name
ribosomal protein L10-like
Synonyms
  • EG238217
  • predicted gene, EG238217
Biotype
protein coding gene
Automated Description
A structural constituent of ribosome. Involved in male meiosis I; ribosomal large subunit assembly; and spermatogenesis. Part of cytosolic large ribosomal subunit. Human ortholog(s) of this gene implicated in spermatogenic failure 63. Orthologous to human RPL10L (ribosomal protein L10 like).
MGI Description
PHENOTYPE: Mice homozygous for a null allele exhibit male infertility associated with testicular hypoplasia, azoospermia,, arrest of male meiosis, male germ cell apoptosis, and impaired ribosome biogenesis in late prophase of meiosis I. [provided by MGI curators]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR11726
Stringency:
Additional filters to further constrain the results:
Species Gene symbol Count Best Best reverse
Method
Ensembl ComparaHGNCHieranoidInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidXenbaseZFIN
Homo sapiensRPL10L4 of 10YesYes  
Rattus norvegicusRpl10l9 of 9YesYes   
Xenopus tropicalisrpl108 of 9YesNo   
Danio reriorpl109 of 10YesYes  
Drosophila melanogasterRpL109 of 9YesYes   
Caenorhabditis elegansrpl-10L9 of 9YesYes   
Saccharomyces cerevisiaeRPL109 of 9YesYes   
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Gene symbolRank Alignment Length (aa) Similarity %Identity %Method Count
Method
Ensembl ComparaHGNCInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidSGD
Rpl10121499997 of 9 
Rpl10-ps327 of 9 

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
Phenotype Term
Annotation details
References
arrest of male meiosis
azoospermia
increased male germ cell apoptosis
male infertility
testis hypoplasia
Showing 1 - 5 of 5 rows
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Disease Associations

Cases where the expected disease association was NOT found
Must provide at least one subject
Cell color indicative of annotation volume

Alleles and Variants

Genome location
Assembly version
GRCm39
Viewer Help
66.3302M66.3303M66.3304M66.3305M66.3306M66.3307M66.3308M66.3309M66.3310M66.3311M
Variant Types and ConsequencesOnly variants associated to alleles are shown in the graphics above. See all variants in JBrowse.
Allele/Variant Symbol
Allele Synonyms
Category
Variant
Variant type
Molecular consequence
Has Disease Annotations
Has Phenotype Annotations
Rpl10lem2Qshallele
Yes
Rpl10lem1Qshallele
Yes
NC_000078.7:g.66330601G>Avariant
SNP
  • synonymous variant
NC_000078.7:g.66330721G>Cvariant
SNP
  • synonymous variant
NC_000078.7:g.66330865C>Avariant
SNP
  • synonymous variant
NC_000078.7:g.66330910C>Tvariant
SNP
  • synonymous variant
NC_000078.7:g.66330895G>Avariant
SNP
  • synonymous variant
NC_000078.7:g.66330961A>Gvariant
SNP
  • synonymous variant
NC_000078.7:g.66331033G>Avariant
SNP
  • synonymous variant
NC_000078.7:g.66330198C>Gvariant
SNP
  • 3 prime UTR variant
Showing 1 - 10 of 27 rows
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Transgenic Alleles

No data available

Models

Model name
Experimental condition
Associated Human Diseases
Associated Phenotypes
Modifier
Source
Rpl10lem1Qsh/Rpl10lem1Qsh [background:] involves: C57BL/6 * DBA/2J
  • arrest of male meiosis
  • azoospermia
MGI
Rpl10lem2Qsh/Rpl10lem2Qsh [background:] involves: C57BL/6 * DBA/2J
  • testis hypoplasia
MGI
Showing 1 - 2 of 2 rows
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Sequence Feature Viewer

Genome location
Assembly version
GRCm39
Viewer Help
66.3302M66.3303M66.3304M66.3305M66.3306M66.3307M66.3308M66.3309M66.3310M66.3311M

Sequence Details

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Expression

Primary Sources
Other Sources
Must provide at least one subject
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

8 interactor genes based on 8 annotations
Rpl10l molecule type
Interactor gene
Interactor species
Interactor molecule type
Detection methods
Source
Reference
protein
Atxn1Mus musculus
protein
  • proximity labelling technology
PMID:30457570
protein
CfdMus musculus
protein
  • affinity chromatography technology
PMID:30550785
protein
Fancd2Mus musculus
protein
  • affinity chromatography technology
PMID:28378742
protein
Fndc5Mus musculus
protein
  • affinity chromatography technology
PMID:30550785
protein
Fzr1Mus musculus
protein
  • affinity chromatography technology
PMID:32434143
protein
HnrnpkMus musculus
protein
  • affinity chromatography technology
PMID:26336360
protein
Sting1Mus musculus
protein
  • proximity labelling technology
PMID:32554809
protein
Usp7Mus musculus
protein
  • affinity chromatography technology
PMID:37196079
Showing 1 - 8 of 8 rows
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Genetic Interactions

No data available