Gene

Chrna4

Species
Mus musculus
Symbol
Chrna4
Name
cholinergic receptor, nicotinic, alpha polypeptide 4
Synonyms
  • a4 nicotinic receptor
  • acetylcholine receptor alpha 4 neural
Biotype
protein coding gene
Automated Description
Enables acetylcholine-gated monoatomic cation-selective channel activity. Contributes to acetylcholine receptor activity. Involved in presynaptic modulation of chemical synaptic transmission. Acts upstream of or within several processes, including behavioral response to nicotine; neuronal action potential; and synaptic signaling. Located in external side of plasma membrane. Part of acetylcholine-gated channel complex. Is active in dopaminergic synapse and presynaptic membrane. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in autosomal dominant nocturnal frontal lobe epilepsy 1 and nicotine dependence. Orthologous to human CHRNA4 (cholinergic receptor nicotinic alpha 4 subunit).
MGI Description
PHENOTYPE: Nullizygous mice may show reduced chemically-elicited analgesia, susceptibility to seizures, increased anxiety, and altered behavioral responses to nicotine or a new environment. Homozygotes for any of several knock-in alleles exhibit altered nervous system physiology and/or sensitivity to nicotine. [provided by MGI curators]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR18945
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
GRCm39
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180.666M180.668M180.670M180.672M180.674M180.676M180.678M180.680M180.682M180.684M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions