Version: 8.0.0Date: Tue Jan 28 2025
Gene
Actb
- Species
- Mus musculus
- Symbol
- Actb
- Name
- actin, beta
- Synonyms
- A-X actin-like protein
- Actx
- Biotype
- protein coding gene
- Automated Description
- Predicted to enable several functions, including ATP hydrolysis activity; Tat protein binding activity; and enzyme binding activity. Predicted to be a structural constituent of postsynaptic actin cytoskeleton. Involved in regulation of synaptic vesicle endocytosis. Located in several cellular components, including brush border; cortical cytoskeleton; and cytosol. Is active in Schaffer collateral - CA1 synapse and calyx of Held. Is expressed in several structures, including brain; early conceptus; gonad; jaw; and musculature. Human ortholog(s) of this gene implicated in Baraitser-Winter syndrome 1 and thrombocytopenia. Orthologous to human ACTB (actin beta).
- MGI Description
- PHENOTYPE: Homozygous null mutants are embryonic lethal. Homozygotes for a hypomorphic targeted mutation develop normally until embryonic day 8.5; are growth retarded by day 9.5 and die shortly thereafter. [provided by MGI curators]
- Cross References
- Additional Information
- Literature
Orthology
- Gene tree
- PANTHER:PTHR11937
Links to orthology data in JBrowse by filter level: Stringent, Moderate, No filter, Best and Best Reverse
Phenotypes
- Primary Sources
- Other Sources
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Disease Associations
Cases where the expected disease association was NOT found
Cell color indicative of annotation volume
No data available
Alleles and Variants
Allele/Variant Symbol | Allele Synonyms | Category | Variant | Variant type | Molecular consequence | Has Disease Annotations | Has Phenotype Annotations |
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Transgenic Alleles
Species (carrying the transgene) | Allele symbol | Transgenic construct | Expressed components | Knock-down targets | Regulatory regions | Has Disease Annotations | Has Phenotype Annotations |
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Models
Model name | Experimental condition | Associated Human Diseases | Associated Phenotypes | Modifier | Source |
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Sequence Feature Viewer
- Genome location
- Chr5:142888870...142892509 - (3.64 kb)
- Assembly version
- GRCm39
- Viewer Help
Data currently unavailable; sequence viewer under construction
Expression
- Primary Sources
- Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.