Species

Mus musculus

Symbol

Adrb1

Name

adrenergic receptor, beta 1

Synonyms

Adrb-1
B1AR

Biotype

protein coding gene

Automated Description

Enables G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential and beta1-adrenergic receptor activity. Involved in positive regulation of cold-induced thermogenesis and regulation of circadian sleep/wake cycle, sleep. Acts upstream of or within several processes, including brown fat cell differentiation; diet induced thermogenesis; and regulation of systemic arterial blood pressure by norepinephrine-epinephrine. Located in membrane. Is active in Schaffer collateral - CA1 synapse and neuronal dense core vesicle. Is expressed in several structures, including brain; exocrine gland; hemolymphoid system gland; intestine; and liver and biliary system. Human ortholog(s) of this gene implicated in several diseases, including chronic obstructive pulmonary disease; hypertension (multiple); low tension glaucoma; obstructive sleep apnea; and periodontitis. Orthologous to human ADRB1 (adrenoceptor beta 1).

MGI Description

PHENOTYPE: Most mice homozygous for targeted mutations that inactivate the gene die prenatally, with the penetrance of lethality showing strain dependence. Surviving knockouts appear normal, but lack the chronotropic and inotropic responses seen in wild-type mice when beta-AR agonists such as isoproterenol are administered. [provided by MGI curators]

Cross References

Additional Information

Literature

Orthology

Gene tree: PANTHER:PTHR24248

Links to orthology data in JBrowse by filter level: Stringent, Moderate, No filter, Best and Best Reverse

Paralogy

Function - GO Annotations

Show functions with at least one experimental evidence

Pathways

No data available

Phenotypes

Primary Sources

MGI

Other Sources

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Disease Associations

Include negative annotationsCases where the expected disease association was NOT found

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Alleles and Variants

Allele/Variant Symbol	Allele Synonyms	Category	Variant	Variant type	Molecular consequence	Has Disease Annotations	Has Phenotype Annotations
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Transgenic Alleles

Species (carrying the transgene)	Allele symbol	Transgenic construct	Expressed components	Knock-down targets	Regulatory regions	Has Disease Annotations	Has Phenotype Annotations
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Models

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Sequence Feature Viewer

Genome location

Chr19:56710549...56713582 + (3.03 kb)

Assembly version

GRCm39

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Data currently unavailable; sequence viewer under construction

Sequence Details

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Expression

Primary Sources

Other Sources

Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Adrb1 molecule type	Interactor gene	Interactor species	Interactor molecule type	Detection methods	Source	Reference
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Genetic Interactions

Adrb1 role	Adrb1 genetic perturbation	Interactor gene	Interactor species	Interactor role	Interactor genetic perturbation	Interaction type	Phenotype or trait	Source	Reference
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