Version: 8.0.0
Date: Tue Jan 28 2025
Apoa4
Mus musculusMGI:88051
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

Apoa4

Species
Mus musculus
Symbol
Apoa4
Name
apolipoprotein A-IV
Synonyms
  • Apo-AIV
  • Apoa-4
Biotype
protein coding gene
Automated Description
Predicted to enable several functions, including cation binding activity; cholesterol transfer activity; and phosphatidylcholine-sterol O-acyltransferase activator activity. Involved in innate immune response in mucosa and response to stilbenoid. Acts upstream of or within regulation of intestinal cholesterol absorption. Located in extracellular space. Is expressed in embryo and liver. Human ortholog(s) of this gene implicated in Alzheimer's disease; colitis; myocardial infarction; and ulcerative colitis. Orthologous to human APOA4 (apolipoprotein A4).
MGI Description
PHENOTYPE: Mice homozygous for disruption of this gene have lower HDL cholesterol levels but normal lipid absorption, growth, and feeding behavior. [provided by MGI curators]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR18976
Stringency:
Additional filters to further constrain the results:
Species Gene symbol Count Best Best reverse
Method
Ensembl ComparaHGNCHieranoidInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidXenbaseZFIN
Homo sapiensAPOA410 of 10YesYes☑☑☑☑☑☑☑☑☑☑  
Rattus norvegicusApoa49 of 9YesYes☑ ☑☑☑☑☑☑☑☑  
Xenopus tropicalisapoa48 of 9YesYes☑ ☑☑☑☑☑☑☑☐  
Danio rerioapoa4b.14 of 10YesNo☑ ☑☐☐☐☐☑☐☐ ☑
Danio rerioapoa4a4 of 10YesYes☑ ☑☐☐☐☐☑☐☐ ☑
Danio rerioapoa4b.24 of 10YesNo☑ ☑☐☐☐☐☑☐☐ ☑
Danio rerioapoa4b.31 of 10NoYes☐ ☐☐☐☐☐☐☐☐ ☑
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Gene symbolRank Alignment Length (aa) Similarity %Identity %Method Count
Method
Ensembl ComparaHGNCInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidSGD
Apoa5136348253 of 9☑☐☐☐☐☐☑☑☐ 
Apoa1228650253 of 9☑☐☐☐☐☐☑☑☐ 
Apoe332644213 of 9☑☐☐☐☐☐☑☑☐ 

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
Phenotype Term
Annotation details
References
abnormal cholesterol homeostasis
abnormal lipid homeostasis
decreased circulating cholesterol level
decreased circulating HDL cholesterol level
decreased circulating triglyceride level
decreased circulating VLDL triglyceride level
increased food intake
increased susceptibility to induced colitis
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Disease Associations

Cases where the expected disease association was NOT found
Must provide at least one subject
Cell color indicative of annotation volume
Species
Gene
Association
Disease Qualifier
Disease
Evidence
Source
Based On
References
No records match query. Try removing filters.
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    Alleles and Variants

    Genome location
    Assembly version
    GRCm39
    Viewer Help
    Data currently unavailable; sequence viewer under construction
    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
    Has Disease Annotations
    Has Phenotype Annotations
    Apoa4em1Smoc
    • Apoa4em1(sGFP-P2A-nLacZ-wpre-polyA)Smoc
    		allele
    Apoa4em1(IMPC)Hmguallele
    Apoa4em1Gpt
    • Apoa4em1Cflox
    		allele
    Apoa4tm1Bres
    • apoA-IV -
    		allele
    		Yes
    NC_000075.7:g.46152921C>Tvariant
    SNP
    • intron variant
    NC_000075.7:g.46152925A>Tvariant
    SNP
    • intron variant
    NC_000075.7:g.46153619T>Cvariant
    SNP
    • synonymous variant
    NC_000075.7:g.46153609G>Avariant
    SNP
    • missense variant
    NC_000075.7:g.46152339T>Cvariant
    SNP
    • 5 prime UTR variant
    NC_000075.7:g.46152554C>Tvariant
    SNP
    • intron variant
    Showing 1 - 10 of 60 rows
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    View detailed Alleles/Variants information
    Download all Alleles/Variants for all genes of the species

    Transgenic Alleles

    No data available

    Models

    Model name
    Experimental condition
    Associated Human Diseases
    Associated Phenotypes
    Modifier
    Source
    Apoa4tm1Bres/Apoa4tm1Bres Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas/? [background:] involves: 129S4/SvJae * C57BL/6 * SJL
    • abnormal long-term spatial reference memory
    • abnormal spatial learning
    		MGI
    Apoa4tm1Bres/Apoa4tm1Bres [background:] B6.129S4-Apoa4tm1Bres
    • increased susceptibility to induced colitis
    		MGI
    Apoa4tm1Bres/Apoa4tm1Bres [background:] either: 129S4/SvJae or (involves: 129S4/SvJae * C57BL/6)
    • abnormal cholesterol homeostasis
    • abnormal lipid homeostasis
    		MGI
    Showing 1 - 3 of 3 rows
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    Sequence Feature Viewer

    Genome location
    Assembly version
    GRCm39
    Viewer Help
    Data currently unavailable; sequence viewer under construction

    Sequence Details

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    Expression

    Primary Sources
    Other Sources
    Must provide at least one subject
    Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

    Molecular Interactions

    2 interactor genes based on 3 annotations
    Apoa4 molecule type
    Interactor gene
    Interactor species
    Interactor molecule type
    Detection methods
    Source
    Reference
    protein
    		ApobMus musculus
    protein
    • biochemical
    		PMID:7592581
    protein
    		ApobMus musculus
    protein
    • biochemical
    		PMID:32325033
    protein
    		TtpalMus musculus
    protein
    • biochemical
    		PMID:32325033
    Showing 1 - 3 of 3 rows
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    Genetic Interactions

    No data available