Gene

Areg

Species
Mus musculus
Symbol
Areg
Name
amphiregulin
Synonyms
  • AR
  • Mcub
Biotype
protein coding gene
Automated Description
Enables receptor ligand activity and transmembrane receptor protein tyrosine kinase activator activity. Involved in epidermal growth factor receptor signaling pathway. Acts upstream of or within several processes, including mammary gland development; positive regulation of peptidyl-tyrosine phosphorylation; and response to estradiol. Located in cytoplasm and nucleus. Is active in extracellular space. Is expressed in several structures, including alimentary system; heart; lung; metanephros; and submandibular gland primordium. Human ortholog(s) of this gene implicated in breast cancer. Orthologous to human AREG (amphiregulin).
MGI Description
PHENOTYPE: Homozygotes for a targeted null mutation exhibit impaired development of mammary gland ducts in pubescent females. Mutant ducts show retarded elongation with few terminal end buds. [provided by MGI curators]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR10740
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
GRCm39
Viewer Help
91.288M91.289M91.290M91.291M91.292M91.293M91.294M91.295M91.296M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions