Gene

Arsb

Species
Mus musculus
Symbol
Arsb
Name
arylsulfatase B
Synonyms
  • 1110007C02Rik
  • AI480648
Biotype
protein coding gene
Automated Description
Enables N-acetylgalactosamine-6-sulfatase activity and arylsulfatase activity. Involved in dermatan sulfate catabolic process. Acts upstream of or within anterior head development. Located in cell surface. Is active in lysosome. Is expressed in skeleton. Used to study mucopolysaccharidosis VI. Human ortholog(s) of this gene implicated in mucopolysaccharidosis VI. Orthologous to human ARSB (arylsulfatase B).
MGI Description
PHENOTYPE: Homozygous mutation of this gene results in development of shortened limbs and snout and a broadened head after 4 weeks of age. Mutant animals have elevated concentrations of glucosaminoglycans in the urine and irregular cartilage structure. [provided by MGI curators]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR10342
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
GRCm39
Viewer Help
93.92M93.94M93.96M93.98M94.00M94.02M94.04M94.06M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions