Gene

Bglap2

Species
Mus musculus
Symbol
Bglap2
Name
bone gamma-carboxyglutamate protein 2
Synonyms
  • Bgp
  • Bgpr
Biotype
protein coding gene
Automated Description
Enables hormone activity and hydroxyapatite binding activity. A structural constituent of bone. Involved in several processes, including negative regulation of bone development; regulation of testosterone biosynthetic process; and type B pancreatic cell proliferation. Acts upstream of or within lipid catabolic process; pancreas development; and positive regulation of insulin secretion. Located in extracellular space. Is active in extracellular region. Is expressed in several structures, including forelimb; jaw; skeleton; and tongue. Human ortholog(s) of this gene implicated in osteoarthritis; osteoporosis; prostate cancer; rheumatoid arthritis; and vitamin K deficiency bleeding. Orthologous to human BGLAP (bone gamma-carboxyglutamate protein).
MGI Description
PHENOTYPE: Mice homozygous for a knock-out allele of both Bglap1 and Bglap2 exhibit decreased circulating insulin, impaired glucose tolerance, increased adipose tissue, increased bone density, and decreased male fertility. [provided by MGI curators]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR14235
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
GRCm39
Viewer Help
88.2851M88.2852M88.2853M88.2854M88.2855M88.2856M88.2857M88.2858M88.2859M88.2860M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions