Enables hormone activity and hydroxyapatite binding activity. A structural constituent of bone. Involved in several processes, including negative regulation of bone development; regulation of testosterone biosynthetic process; and type B pancreatic cell proliferation. Acts upstream of or within lipid catabolic process; pancreas development; and positive regulation of insulin secretion. Located in extracellular space. Is active in extracellular region. Is expressed in several structures, including forelimb; jaw; skeleton; and tongue. Human ortholog(s) of this gene implicated in osteoarthritis; osteoporosis; prostate cancer; rheumatoid arthritis; and vitamin K deficiency bleeding. Orthologous to human BGLAP (bone gamma-carboxyglutamate protein).
MGI Description
PHENOTYPE: Mice homozygous for a knock-out allele of both Bglap1 and Bglap2 exhibit decreased circulating insulin, impaired glucose tolerance, increased adipose tissue, increased bone density, and decreased male fertility. [provided by MGI curators]