Gene

Bmp5

Species
Mus musculus
Symbol
Bmp5
Name
bone morphogenetic protein 5
Synonyms
  • AU023399
  • expressed sequence AU023399
Biotype
protein coding gene
Automated Description
Predicted to enable BMP receptor binding activity and cytokine activity. Involved in several processes, including allantois development; chordate embryonic development; and heart development. Acts upstream of or within several processes, including anterior head development; ear development; and male genitalia development. Predicted to be located in vesicle. Predicted to be active in extracellular space. Is expressed in several structures, including bone; central nervous system; embryo mesenchyme; limb; and sensory organ. Used to study Meier-Gorlin syndrome. Orthologous to human BMP5 (bone morphogenetic protein 5).
MGI Description
PHENOTYPE: Homozygous recessive mutants have shortened, slightly ruffled external ears due to a defective cartilage framework affecting the whole skeleton; a series of genomic deletions of the region cause embryonic lethality. [provided by MGI curators]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR11848
No data available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

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Other Sources
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
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      Alleles and Variants

      Allele/Variant Symbol
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      Variant type
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        Transgenic Alleles

        Species
        (carrying the transgene)
        Allele symbol
        Transgenic construct
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          Models

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            Sequence Feature Viewer

            Genome location
            Assembly version
            GRCm39
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            75.70M75.72M75.74M75.76M75.78M75.80M

            Sequence Details

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            Expression

            Primary Sources
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            Bmp5 molecule type
            Interactor gene
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              Genetic Interactions

              Bmp5 role
              Bmp5 genetic perturbation
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