Gene

Capn2

Species
Mus musculus
Symbol
Capn2
Name
calpain 2
Synonyms
  • AI326419
  • Capa-2
Biotype
protein coding gene
Automated Description
Enables calcium-dependent cysteine-type endopeptidase activity. Involved in several processes, including cellular response to amino acid stimulus; protein catabolic process at postsynapse; and synaptic vesicle endocytosis. Acts upstream of or within blastocyst development and myoblast fusion. Located in several cellular components, including chromatin; cytosol; and lysosome. Is active in postsynapse. Is expressed in several structures, including central nervous system; lens epithelium; molar; oral region epithelium; and skin. Orthologous to human CAPN2 (calpain 2).
MGI Description
PHENOTYPE: Homozygous inactivation of this gene leads to complete prenatal lethality. Mice homozygous for one null allele display placental dysfunction, thin ventricular walls, and peripheral vessel failure. [provided by MGI curators]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR10183
No data available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
Phenotype Term
Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    Gene
    Association
    Disease Qualifier
    Disease
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      Alleles and Variants

      Allele/Variant Symbol
      Allele Synonyms
      Category
      Variant
      Variant type
      Molecular consequence
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        Transgenic Alleles

        Species
        (carrying the transgene)
        Allele symbol
        Transgenic construct
        Expressed components
        Knock-down targets
        Regulatory regions
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          Models

          Model name
          Experimental condition
          Associated Human Diseases
          Associated Phenotypes
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            Sequence Feature Viewer

            Genome location
            Assembly version
            GRCm39
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            182.295M182.300M182.305M182.310M182.315M182.320M182.325M182.330M182.335M182.340M182.345M

            Sequence Details

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            Expression

            Primary Sources
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            Capn2 molecule type
            Interactor gene
            Interactor species
            Interactor molecule type
            Detection methods
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              Genetic Interactions

              Capn2 role
              Capn2 genetic perturbation
              Interactor gene
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              Interactor role
              Interactor genetic perturbation
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              Phenotype or trait
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