Gene

Ctnnb1

Species
Mus musculus
Symbol
Ctnnb1
Name
catenin beta 1
Synonyms
  • batface
  • beta catenin
Biotype
protein coding gene
Automated Description
Enables several functions, including alpha-catenin binding activity; disordered domain specific binding activity; and enzyme binding activity. Involved in several processes, including nervous system development; regulation of neurogenesis; and regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including embryonic morphogenesis; kidney development; and positive regulation of cell population proliferation. Located in several cellular components, including apicolateral plasma membrane; basolateral plasma membrane; and euchromatin. Part of several cellular components, including Scrib-APC-beta-catenin complex; Wnt signalosome; and nucleus. Is active in several cellular components, including Schaffer collateral - CA1 synapse; postsynaptic density, intracellular component; and synaptic membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Used to study autism spectrum disorder; exudative vitreoretinopathy; otitis media; reproductive organ cancer (multiple); and urinary bladder cancer. Human ortholog(s) of this gene implicated in several diseases, including autosomal dominant intellectual developmental disorder 19; exudative vitreoretinopathy 7; hepatocellular carcinoma (multiple); nephroblastoma; and pilomatrixoma. Orthologous to human CTNNB1 (catenin beta 1).
MGI Description
PHENOTYPE: Homozygous null embryos show anterior-posterior axis formation anomalies, but develop to E7. Multiple conditional mutations have shown defects in distinct stem cell types that result in proliferation defects, such as intestinal polyps, brain and spinal cord size anomalies, etc. Inducible KO in endothelial cells affects retinal angiogenesis. [provided by MGI curators]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR45976
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
GRCm39
Viewer Help
120.765M120.770M120.775M120.780M120.785M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions