Gene

Cdk1

Species
Mus musculus
Symbol
Cdk1
Name
cyclin dependent kinase 1
Synonyms
  • Cdc2
  • Cdc2a
Biotype
protein coding gene
Automated Description
Enables Hsp70 protein binding activity; chromatin binding activity; and cyclin-dependent protein serine/threonine kinase activity. Acts upstream of or within several processes, including fibroblast proliferation; mitotic G2 DNA damage checkpoint signaling; and mitotic cell cycle phase transition. Part of cyclin A2-CDK1 complex. Colocalizes with mitochondrial matrix. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in breast cancer; cervical cancer; and urinary bladder cancer. Orthologous to human CDK1 (cyclin dependent kinase 1).
MGI Description
PHENOTYPE: Mice homozygous for a null allele die prior to E1.5. [provided by MGI curators]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR24056
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
GRCm39
Viewer Help
69.172M69.174M69.176M69.178M69.180M69.182M69.184M69.186M69.188M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions