Gene

F2

Species
Mus musculus
Symbol
F2
Name
coagulation factor II
Synonyms
  • Cf-2
  • Cf2
Biotype
protein coding gene
Automated Description
Enables serine-type endopeptidase activity. Involved in G protein-coupled receptor signaling pathway; ligand-gated ion channel signaling pathway; and positive regulation of insulin secretion. Acts upstream of or within several processes, including platelet activation; positive regulation of cell growth; and positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction. Located in collagen-containing extracellular matrix. Is expressed in several structures, including adrenal gland; gonad; liver; musculoskeletal system; and yolk sac endoderm. Human ortholog(s) of this gene implicated in several diseases, including X-linked recessive disease (multiple); appendicitis; artery disease (multiple); autoimmune disease (multiple); and thrombophilia (multiple). Orthologous to human F2 (coagulation factor II, thrombin).
MGI Description
PHENOTYPE: Homozygotes for targeted null mutations exhibit defects in yolk sac vasculature, internal bleeding, tissue necrosis, and die in mid- to late-gestation, or rarely, a few days after birth. [provided by MGI curators]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR24254
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
GRCm39
Viewer Help
91.456M91.457M91.458M91.459M91.460M91.461M91.462M91.463M91.464M91.465M91.466M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions