Species

Mus musculus

Symbol

Csk

Name

c-src tyrosine kinase

Synonyms

AW212630
expressed sequence AW212630

Biotype

protein coding gene

Automated Description

Predicted to enable several functions, including enzyme binding activity; non-membrane spanning protein tyrosine kinase activity; and proline-rich region binding activity. Acts upstream of or within negative regulation of cell population proliferation. Located in cell-cell junction. Is expressed in several structures, including central nervous system; genitourinary system; gut; hemolymphoid system; and liver and biliary system. Orthologous to human CSK (C-terminal Src kinase).

MGI Description

PHENOTYPE: Homozygotes for targeted null mutations exhibit growth retardation, neural tube defects, and developmental arrest at the 10-12 somite stage. Mutants die between embryonic days nine and ten. [provided by MGI curators]

Cross References

Additional Information

Literature

Orthology

Gene tree: PANTHER:PTHR24418

Links to orthology data in JBrowse by filter level: Stringent, Moderate, No filter, Best and Best Reverse

Paralogy

Function - GO Annotations

Show functions with at least one experimental evidence

Pathways

No data available

Phenotypes

Primary Sources

MGI

Other Sources

Disease Associations

Include negative annotationsCases where the expected disease association was NOT found

Cell color indicative of annotation volume

Alleles and Variants

Download all Alleles/Variants for all genes of the species

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location

Chr9:57533929...57560758 - (26.83 kb)

Assembly version

GRCm39

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Data currently unavailable; sequence viewer under construction

Sequence Details

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Expression