Gene

Cybb

Species
Mus musculus
Symbol
Cybb
Name
cytochrome b-245, beta polypeptide
Synonyms
  • C88302
  • Cgd
Biotype
protein coding gene
Automated Description
Enables superoxide-generating NAD(P)H oxidase activity. Involved in inflammatory response; innate immune response; and superoxide metabolic process. Acts upstream of or within hydrogen peroxide biosynthetic process. Located in phagocytic vesicle and plasma membrane. Part of NADPH oxidase complex. Is expressed in several structures, including alimentary system; brain; cardiac muscle tissue; genitourinary system; and immune system. Used to study chronic granulomatous disease and systemic lupus erythematosus. Human ortholog(s) of this gene implicated in X-linked chronic granulomatous disease; chronic granulomatous disease; and immunodeficiency 34. Orthologous to human CYBB (cytochrome b-245 beta chain).
MGI Description
PHENOTYPE: Nullizygous mice show alterations in acute inflammation, synaptic plasticity, memory, metastatic potential, susceptibility to infection and induced GI injury, inflammatory response to chemical peritonitis, vascular response to Ang II, hypoxia-induced LV remodeling, and L-NAME-caused renal responses. Homozygotes for a null allele show postnatal lethality, decreased birth weight, cardiac septal and valve defects, and impaired atrioventricular cushion development. [provided by MGI curators]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR11972
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
GRCm39
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9.305M9.310M9.315M9.320M9.325M9.330M9.335M9.340M9.345M9.350M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions