cytochrome P450, family 2, subfamily f, polypeptide 2
Synonyms
Cyp2f
Cyp2f1
Biotype
protein coding gene
Automated Description
Predicted to enable arachidonate epoxygenase activity; heme binding activity; and oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen. Acts upstream of or within naphthalene catabolic process and response to toxic substance. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in cytoplasm and intracellular membrane-bounded organelle. Is expressed in several structures, including alimentary system; nose; pharyngo-tympanic tube; respiratory system; and sublingual gland primordium. Orthologous to several human genes including CYP2F1 (cytochrome P450 family 2 subfamily F member 1).
MGI Description
PHENOTYPE: Mice homozygous for a knock-out allele exhibit resistance to napthalene-induced toxicity in the lungs. [provided by MGI curators]