Version: 8.0.0
Date: Tue Jan 28 2025
Dnajc5
Mus musculusMGI:892995
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

Dnajc5

Species
Mus musculus
Symbol
Dnajc5
Name
DnaJ heat shock protein family (Hsp40) member C5
Synonyms
  • 2610314I24Rik
  • AU018536
Biotype
protein coding gene
Automated Description
Predicted to enable ATP-dependent protein binding activity. Involved in chaperone-mediated protein folding and regulation of synaptic vesicle cycle. Acts upstream of or within negative regulation of neuron apoptotic process. Located in synaptic vesicle. Is active in neuromuscular junction and presynapse. Human ortholog(s) of this gene implicated in neuronal ceroid lipofuscinosis 4. Orthologous to human DNAJC5 (DnaJ heat shock protein family (Hsp40) member C5).
MGI Description
PHENOTYPE: Mice homozygous for disruptions in this gene die within the first 3 months of live and abnormalities in their neuromuscular synapses. This results in various defects in movement and coordination. [provided by MGI curators]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR44027
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    No data available

    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
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      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
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      Has Phenotype Annotations
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        Models

        Model name
        Experimental condition
        Associated Human Diseases
        Associated Phenotypes
        Modifier
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          Sequence Feature Viewer

          Genome location
          Assembly version
          GRCm39
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          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          Dnajc5 molecule type
          Interactor gene
          Interactor species
          Interactor molecule type
          Detection methods
          Source
          Reference
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            Genetic Interactions

            Dnajc5 role
            Dnajc5 genetic perturbation
            Interactor gene
            Interactor species
            Interactor role
            Interactor genetic perturbation
            Interaction type
            Phenotype or trait
            Source
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