Gene

Sgca

Species
Mus musculus
Symbol
Sgca
Name
sarcoglycan, alpha (dystrophin-associated glycoprotein)
Synonyms
  • 50DAG
  • adhalin
Biotype
protein coding gene
Automated Description
Predicted to enable calcium ion binding activity. Predicted to be involved in response to denervation involved in regulation of muscle adaptation and skeletal muscle tissue regeneration. Predicted to act upstream of or within membrane organization. Located in cell-cell junction; membrane raft; and sarcolemma. Part of sarcoglycan complex. Is expressed in several structures, including foregut; heart; limb interdigital region; musculature; and paraxial mesenchyme. Used to study autosomal recessive limb-girdle muscular dystrophy type 2D. Human ortholog(s) of this gene implicated in autosomal recessive limb-girdle muscular dystrophy type 2D and muscular dystrophy. Orthologous to human SGCA (sarcoglycan alpha).
MGI Description
PHENOTYPE: Homozygous mutation of this gene results in muscle abnormalities, with decreased skeletal muscle force and stiffness and muscular dystrophy. [provided by MGI curators]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR10132
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
GRCm39
Viewer Help
94.854M94.856M94.858M94.860M94.862M94.864M94.866M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions