Version: 8.0.0
Date: Tue Jan 28 2025
Dvl1
Mus musculusMGI:94941
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

Dvl1

Species
Mus musculus
Symbol
Dvl1
Name
dishevelled segment polarity protein 1
Synonyms
  • dvl-1
Biotype
protein coding gene
Automated Description
Enables beta-catenin binding activity and protein kinase binding activity. Involved in several processes, including heart morphogenesis; protein stabilization; and synapse organization. Acts upstream of with a positive effect on synaptic vesicle exocytosis. Acts upstream of or within several processes, including embryonic morphogenesis; neuron projection morphogenesis; and regulation of protein phosphorylation. Located in several cellular components, including axon; clathrin-coated vesicle; and microtubule cytoskeleton. Part of Wnt signalosome. Is active in several cellular components, including Schaffer collateral - CA1 synapse; neuronal dense core vesicle; and postsynaptic density. Colocalizes with cytoplasm. Is expressed in several structures, including central nervous system; early conceptus; eye; genitourinary system; and skin. Human ortholog(s) of this gene implicated in DiGeorge syndrome and autosomal dominant Robinow syndrome 2. Orthologous to several human genes including DVL1 (dishevelled segment polarity protein 1).
MGI Description
PHENOTYPE: Homozygous targeted mutants are viable and fertile, but show a number of behavioral changes including deficient nest-building, less huddling contact during sleep, reduced subordinate responses, and other social interaction deficits. [provided by MGI curators]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR10878
No data available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    Gene
    Association
    Disease Qualifier
    Disease
    Evidence
    Source
    Based On
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      Alleles and Variants

      Allele/Variant Symbol
      Allele Synonyms
      Category
      Variant
      Variant type
      Molecular consequence
      Has Disease Annotations
      Has Phenotype Annotations
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        Download all Alleles/Variants for all genes of the species

        Transgenic Alleles

        Species
        (carrying the transgene)
        Allele symbol
        Transgenic construct
        Expressed components
        Knock-down targets
        Regulatory regions
        Has Disease Annotations
        Has Phenotype Annotations
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          Models

          Model name
          Experimental condition
          Associated Human Diseases
          Associated Phenotypes
          Modifier
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            Sequence Feature Viewer

            Genome location
            Assembly version
            GRCm39
            Viewer Help
            155.932M155.934M155.936M155.938M155.940M155.942M

            Sequence Details

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            Expression

            Primary Sources
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            Dvl1 molecule type
            Interactor gene
            Interactor species
            Interactor molecule type
            Detection methods
            Source
            Reference
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              Genetic Interactions

              Dvl1 role
              Dvl1 genetic perturbation
              Interactor gene
              Interactor species
              Interactor role
              Interactor genetic perturbation
              Interaction type
              Phenotype or trait
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