Version: 8.0.0
Date: Tue Jan 28 2025
Eif4a1
Mus musculusMGI:95303
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

Eif4a1

Species
Mus musculus
Symbol
Eif4a1
Name
eukaryotic translation initiation factor 4A1
Synonyms
  • Eif4
  • eukaryotic translation initiation factor 4
Biotype
protein coding gene
Automated Description
Predicted to enable double-stranded RNA binding activity and translation initiation factor activity. Predicted to be involved in cytoplasmic translational initiation and positive regulation of transcription by RNA polymerase II. Predicted to be located in nuclear stress granule; perinuclear region of cytoplasm; and plasma membrane. Predicted to be part of eukaryotic translation initiation factor 4F complex. Is expressed in several structures, including central nervous system; liver; lung; ovary; and sensory organ. Orthologous to human EIF4A1 (eukaryotic translation initiation factor 4A1).
MGI Description
PHENOTYPE: Mice with loss of expression in developing B cells display near complete absence of splenic B cells. Loss of expression in mature B cells results in impaired development after activation. [provided by MGI curators]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR24031
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    No data available

    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
    Has Disease Annotations
    Has Phenotype Annotations
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      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
      Has Disease Annotations
      Has Phenotype Annotations
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        Models

        Model name
        Experimental condition
        Associated Human Diseases
        Associated Phenotypes
        Modifier
        Source
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          Sequence Feature Viewer

          Genome location
          Assembly version
          GRCm39
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          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          Eif4a1 molecule type
          Interactor gene
          Interactor species
          Interactor molecule type
          Detection methods
          Source
          Reference
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            Genetic Interactions

            Eif4a1 role
            Eif4a1 genetic perturbation
            Interactor gene
            Interactor species
            Interactor role
            Interactor genetic perturbation
            Interaction type
            Phenotype or trait
            Source
            Reference
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