Enables lipid transfer activity; molecular condensate scaffold activity; and phospholipid binding activity. Involved in lipid droplet fusion; lipid storage; and negative regulation of lipid metabolic process. Is active in lipid droplet. Is expressed in several structures, including alimentary system; endocrine gland; genitourinary system; hemolymphoid system gland; and integumental system. Human ortholog(s) of this gene implicated in familial partial lipodystrophy type 5. Orthologous to human CIDEC (cell death inducing DFFA like effector c).
MGI Description
PHENOTYPE: Nullizygous mice exhibit leaness, high energy expenditure, improved glucose tolerance, altered brown adipocytes, and multilocular fat droplets with enhanced mitochondrial activity and lipolysis in white adipocytes, and may show resistance to age related and diet-induced obesity and liver steatosis. [provided by MGI curators]