gamma-aminobutyric acid type A receptor subunit rho 1
Synonyms
GABA-C
Biotype
protein coding gene
Automated Description
Enables ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential. Involved in modulation of chemical synaptic transmission. Located in plasma membrane. Is active in several cellular components, including GABA-ergic synapse; glutamatergic synapse; and presynaptic membrane. Is expressed in brain; cerebral cortex; and retina. Orthologous to human GABRR1 (gamma-aminobutyric acid type A receptor subunit rho1).
MGI Description
PHENOTYPE: Mice homozygous for a knock-out allele display altered visual processing in the retina. Mice homozygous for a different knock-out allele exhibit alterations of mechanical pain sensitivity, GABA-inhibited spinal cord responses, and olfactory function. [provided by MGI curators]