Version: 8.0.0
Date: Tue Jan 28 2025
Gna13
Mus musculusMGI:95768
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

Gna13

Species
Mus musculus
Symbol
Gna13
Name
guanine nucleotide binding protein, alpha 13
Synonyms
  • AU024132
  • AU043124
Biotype
protein coding gene
Automated Description
Predicted to enable D5 dopamine receptor binding activity; G protein activity; and G-protein beta/gamma-subunit complex binding activity. Involved in adenylate cyclase-modulating G protein-coupled receptor signaling pathway; regulation of blood pressure; and regulation of postsynapse assembly. Acts upstream of or within several processes, including Rho protein signal transduction; branching involved in blood vessel morphogenesis; and platelet activation. Located in cytoplasm and nucleus. Is active in postsynapse. Is expressed in several structures, including branchial arch; genitourinary system; gut gland; nervous system; and sensory organ. Orthologous to human GNA13 (G protein subunit alpha 13).
MGI Description
PHENOTYPE: Mice homozygous for a targeted null or with an endothelial specific conditional mutation fail to develop an organized vascular system in the yolk sac, show impaired vascular development in some vascular beds in the embryo proper, and die during organogenesis. [provided by MGI curators]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR10218
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    No data available

    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
    Has Disease Annotations
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      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
      Has Disease Annotations
      Has Phenotype Annotations
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        Models

        Model name
        Experimental condition
        Associated Human Diseases
        Associated Phenotypes
        Modifier
        Source
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          Sequence Feature Viewer

          Genome location
          Assembly version
          GRCm39
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          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          Gna13 molecule type
          Interactor gene
          Interactor species
          Interactor molecule type
          Detection methods
          Source
          Reference
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            Genetic Interactions

            Gna13 role
            Gna13 genetic perturbation
            Interactor gene
            Interactor species
            Interactor role
            Interactor genetic perturbation
            Interaction type
            Phenotype or trait
            Source
            Reference
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