Version: 8.0.0
Date: Tue Jan 28 2025
Ighm
Mus musculusMGI:96448
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

Ighm

Species
Mus musculus
Symbol
Ighm
Name
immunoglobulin heavy constant mu
Synonyms
  • AI326478
  • BCR
Biotype
gene segment
Automated Description
Enables several functions, including antigen binding activity; identical protein binding activity; and immunoglobulin receptor binding activity. Involved in pre-B cell allelic exclusion. Acts upstream of or within several processes, including early endosome to late endosome transport; immunoglobulin mediated immune response; and positive regulation of B cell proliferation. Located in external side of plasma membrane; extracellular space; and perinuclear region of cytoplasm. Part of B cell receptor complex and immunoglobulin complex, circulating. Is active in cytoplasm. Is expressed in several structures, including brain; hemolymphoid system; intestine; and liver. Used to study non-Hodgkin lymphoma and type 1 diabetes mellitus. Human ortholog(s) of this gene implicated in agammaglobulinemia 1. Orthologous to human IGHM (immunoglobulin heavy constant mu).
MGI Description
PHENOTYPE: Mice homozygous for a knock-out allele exhibit abnormal immune system morphology and physiology. [provided by MGI curators]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR23411
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    No data available

    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
    Has Disease Annotations
    Has Phenotype Annotations
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      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
      Has Disease Annotations
      Has Phenotype Annotations
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        Models

        Model name
        Experimental condition
        Associated Human Diseases
        Associated Phenotypes
        Modifier
        Source
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          Sequence Feature Viewer

          Genome location
          Assembly version
          GRCm39
          Viewer Help
          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          Ighm molecule type
          Interactor gene
          Interactor species
          Interactor molecule type
          Detection methods
          Source
          Reference
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            Genetic Interactions

            Ighm role
            Ighm genetic perturbation
            Interactor gene
            Interactor species
            Interactor role
            Interactor genetic perturbation
            Interaction type
            Phenotype or trait
            Source
            Reference
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