Gene

Il1b

Species
Mus musculus
Symbol
Il1b
Name
interleukin 1 beta
Synonyms
  • IL-1B
  • Il-1b
Biotype
protein coding gene
Automated Description
Enables cytokine activity. Involved in several processes, including negative regulation of cell communication; positive regulation of cytokine production; and positive regulation of intracellular signal transduction. Acts upstream of or within several processes, including ectopic germ cell programmed cell death; extrinsic apoptotic signaling pathway in absence of ligand; and positive regulation of macromolecule biosynthetic process. Located in extracellular space and secretory granule. Is expressed in several structures, including early conceptus; genitourinary system; hemolymphoid system; intestine; and skin. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); blood platelet disease (multiple); cervix disease (multiple); eye disease (multiple); and lung disease (multiple). Orthologous to human IL1B (interleukin 1 beta).
MGI Description
PHENOTYPE: Homozygous null mutants show impaired contact hypersensitivity and reduced acute-phase inflammatory response. Lung tumors and metastases of B16 melanoma do not occur in null mutant mice, suggesting inability to support tumor invasiveness and angiogenesis. [provided by MGI curators]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR10078
No data available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

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Other Sources
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Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    Gene
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      Alleles and Variants

      Allele/Variant Symbol
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      Variant type
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        Transgenic Alleles

        Species
        (carrying the transgene)
        Allele symbol
        Transgenic construct
        Expressed components
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          Models

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            Sequence Feature Viewer

            Genome location
            Assembly version
            GRCm39
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            129.207M129.208M129.209M129.210M129.211M129.212M129.213M

            Sequence Details

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            Expression

            Primary Sources
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            Il1b molecule type
            Interactor gene
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              Genetic Interactions

              Il1b role
              Il1b genetic perturbation
              Interactor gene
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