Enables interleukin-2 binding activity. Predicted to be involved in cytokine-mediated signaling pathway; immunoglobulin mediated immune response; and positive regulation of phagocytosis. Predicted to act upstream of or within negative regulation of apoptotic process. Located in external side of plasma membrane. Is expressed in heart; hemolymphoid system; liver; thymus; and thymus primordium. Human ortholog(s) of this gene implicated in asthma; immunodeficiency 63; myasthenia gravis; and visceral leishmaniasis. Orthologous to human IL2RB (interleukin 2 receptor subunit beta).
MGI Description
PHENOTYPE: Homozygotes for a targeted null mutation exhibit spontaneous activation of T cells and differentiation of B cells, elevated immunoglobulins including autoantibodies causing hemolytic anemia, granulocytopoiesis, and death after 3 months of age. [provided by MGI curators]