Gene

Il2rb

Species
Mus musculus
Symbol
Il2rb
Name
interleukin 2 receptor, beta chain
Synonyms
  • CD122
  • IL-15 receptor beta chain
Biotype
protein coding gene
Automated Description
Enables interleukin-2 binding activity. Predicted to be involved in cytokine-mediated signaling pathway; immunoglobulin mediated immune response; and positive regulation of phagocytosis. Predicted to act upstream of or within negative regulation of apoptotic process. Located in external side of plasma membrane. Is expressed in heart; hemolymphoid system; liver; thymus; and thymus primordium. Human ortholog(s) of this gene implicated in asthma; immunodeficiency 63; myasthenia gravis; and visceral leishmaniasis. Orthologous to human IL2RB (interleukin 2 receptor subunit beta).
MGI Description
PHENOTYPE: Homozygotes for a targeted null mutation exhibit spontaneous activation of T cells and differentiation of B cells, elevated immunoglobulins including autoantibodies causing hemolytic anemia, granulocytopoiesis, and death after 3 months of age. [provided by MGI curators]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR23037
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
GRCm39
Viewer Help
78.364M78.366M78.368M78.370M78.372M78.374M78.376M78.378M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions