Version: 8.0.0
Date: Tue Jan 28 2025
Itgav
Mus musculusMGI:96608
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

Itgav

Species
Mus musculus
Symbol
Itgav
Name
integrin alpha V
Synonyms
  • 1110004F14Rik
  • 2610028E01Rik
Biotype
protein coding gene
Automated Description
Enables integrin binding activity. Contributes to opsonin binding activity and protein kinase C binding activity. Involved in several processes, including ERK1 and ERK2 cascade; extrinsic apoptotic signaling pathway in absence of ligand; and positive regulation of osteoblast proliferation. Acts upstream of or within blood vessel development. Located in external side of plasma membrane. Part of integrin alphav-beta5 complex and integrin alphav-beta6 complex. Is expressed in several structures, including early conceptus; embryo mesenchyme; jaw; skeletal muscle; and ventricular layer. Human ortholog(s) of this gene implicated in abdominal aortic aneurysm and acute myeloid leukemia. Orthologous to human ITGAV (integrin subunit alpha V).
MGI Description
PHENOTYPE: Homozygotes for a targeted null mutation exhibit placental defects, intracerebral and intestinal hemorrhages, and cleft palate, resulting in death occurring as early as midgestation and as late as shortly after birth. [provided by MGI curators]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR23220
No data available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    Gene
    Association
    Disease Qualifier
    Disease
    Evidence
    Source
    Based On
    References
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      Alleles and Variants

      Allele/Variant Symbol
      Allele Synonyms
      Category
      Variant
      Variant type
      Molecular consequence
      Has Disease Annotations
      Has Phenotype Annotations
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        Transgenic Alleles

        Species
        (carrying the transgene)
        Allele symbol
        Transgenic construct
        Expressed components
        Knock-down targets
        Regulatory regions
        Has Disease Annotations
        Has Phenotype Annotations
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          Models

          Model name
          Experimental condition
          Associated Human Diseases
          Associated Phenotypes
          Modifier
          Source
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            Sequence Feature Viewer

            Genome location
            Assembly version
            GRCm39
            Viewer Help
            83.56M83.57M83.58M83.59M83.60M83.61M83.62M83.63M

            Sequence Details

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            Expression

            Primary Sources
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            Itgav molecule type
            Interactor gene
            Interactor species
            Interactor molecule type
            Detection methods
            Source
            Reference
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              Genetic Interactions

              Itgav role
              Itgav genetic perturbation
              Interactor gene
              Interactor species
              Interactor role
              Interactor genetic perturbation
              Interaction type
              Phenotype or trait
              Source
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