Gene

Kcne1

Species
Mus musculus
Symbol
Kcne1
Name
potassium voltage-gated channel, Isk-related subfamily, member 1
Synonyms
  • Isk
  • MinK
Biotype
protein coding gene
Automated Description
Enables potassium channel regulator activity. Involved in potassium ion transmembrane transport; secretory granule organization; and vestibular nucleus development. Acts upstream of or within epithelial cell maturation; heart contraction; and regulation of heart rate by cardiac conduction. Part of voltage-gated potassium channel complex. Is active in apical plasma membrane. Is expressed in several structures, including ear; embryo ectoderm; genitourinary system; great vessel of heart; and heart. Used to study Jervell-Lange Nielsen syndrome. Human ortholog(s) of this gene implicated in Jervell-Lange Nielsen syndrome; atrial fibrillation; long QT syndrome; and long QT syndrome 5. Orthologous to human KCNE1 (potassium voltage-gated channel subfamily E regulatory subunit 1).
MGI Description
PHENOTYPE: Homozygotes for targeted and spontaneous null mutations exhibit head-shaking, circling, ataxia, and severe deafness associated with inner ear defects. Older mutants show increased numbers of T cells. Study of cardiac myocytes in one line revealed physiologic defects. [provided by MGI curators]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR15282
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
GRCm39
Viewer Help
92.144M92.146M92.148M92.150M92.152M92.154M92.156M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions