Gene

Me1

Species
Mus musculus
Symbol
Me1
Name
malic enzyme 1, NADP(+)-dependent, cytosolic
Synonyms
  • D9Ertd267e
  • DNA segment, Chr 9, ERATO Doi 267, expressed
Biotype
protein coding gene
Automated Description
Enables malate dehydrogenase (decarboxylating) (NADP+) activity. Predicted to be involved in several processes, including carboxylic acid metabolic process; nicotinamide nucleotide metabolic process; and protein homotetramerization. Located in mitochondrion. Is expressed in several structures, including alimentary system; cardiovascular system; genitourinary system; hemolymphoid system gland; and nervous system. Orthologous to human ME1 (malic enzyme 1).
MGI Description
PHENOTYPE: Mice homozygous for a spontaneous allele exhibit decreased body weight on a medium fat diet, altered cytoplasmic malic enzyme activity, and a male-specific reduction in food intake on a high fat diet. [provided by MGI curators]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR23406
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
GRCm39
Viewer Help
86.48M86.50M86.52M86.54M86.56M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions