Gene

Myc

Species
Mus musculus
Symbol
Myc
Name
myelocytomatosis oncogene
Synonyms
  • AU016757
  • bHLHe39
Biotype
protein coding gene
Automated Description
Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and ubiquitin protein ligase binding activity. Involved in several processes, including NK T cell proliferation; positive regulation of metanephric cap mesenchymal cell proliferation; and positive regulation of nucleobase-containing compound metabolic process. Acts upstream of or within several processes, including cellular response to interferon-alpha; detection of mechanical stimulus involved in sensory perception of sound; and positive regulation of apoptotic process. Located in several cellular components, including euchromatin; nuclear body; and perinuclear region of cytoplasm. Part of Myc-Max complex. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; sensory organ; and urinary system. Used to study Burkitt lymphoma; autosomal dominant polycystic kidney disease; breast cancer; hepatocellular carcinoma; and pancreatic carcinoma. Human ortholog(s) of this gene implicated in several diseases, including angiosarcoma; carcinoma (multiple); demyelinating disease; hematologic cancer (multiple); and prostate cancer (multiple). Orthologous to human MYC (MYC proto-oncogene, bHLH transcription factor).
MGI Description
PHENOTYPE: Mutations affect growth and development of heart, pericardium, neural tube, vasculogenesis and erythropoeisis. Homozygous null mutants die by embryonic day 10.5. Heterozygotes have reduced body size and multiorgan hypoplasia; females have small litters. [provided by MGI curators]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR45851
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
GRCm39
Viewer Help
61.8575M61.8580M61.8585M61.8590M61.8595M61.8600M61.8605M61.8610M61.8615M61.8620M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions