Version: 8.0.0
Date: Tue Jan 28 2025
Myod1
Mus musculusMGI:97275
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

Myod1

Species
Mus musculus
Symbol
Myod1
Name
myogenic differentiation 1
Synonyms
  • AI503393
  • bHLHc1
Biotype
protein coding gene
Automated Description
Enables several functions, including DNA binding activity; DNA-binding transcription activator activity, RNA polymerase II-specific; and DNA-binding transcription factor binding activity. Contributes to DNA binding activity. Involved in several processes, including cellular response to estradiol stimulus; positive regulation of snRNA transcription by RNA polymerase II; and skeletal muscle cell differentiation. Acts upstream of or within several processes, including myotube differentiation; regulation of RNA metabolic process; and skeletal muscle fiber adaptation. Located in euchromatin; myofibril; and nucleus. Part of transcription regulator complex. Is expressed in several structures, including alimentary system; embryo mesenchyme; limb; limb bud; and skeletal musculature. Human ortholog(s) of this gene implicated in congenital myopathy 17. Orthologous to human MYOD1 (myogenic differentiation 1).
MGI Description
PHENOTYPE: Mice homozygous for a knock-out allele exhibit abnormal muscle development. [provided by MGI curators]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR11534
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    No data available

    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
    Has Disease Annotations
    Has Phenotype Annotations
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      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
      Has Disease Annotations
      Has Phenotype Annotations
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        Models

        Model name
        Experimental condition
        Associated Human Diseases
        Associated Phenotypes
        Modifier
        Source
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          Sequence Feature Viewer

          Genome location
          Assembly version
          GRCm39
          Viewer Help
          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          Myod1 molecule type
          Interactor gene
          Interactor species
          Interactor molecule type
          Detection methods
          Source
          Reference
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            Genetic Interactions

            Myod1 role
            Myod1 genetic perturbation
            Interactor gene
            Interactor species
            Interactor role
            Interactor genetic perturbation
            Interaction type
            Phenotype or trait
            Source
            Reference
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