Gene

Nedd4

Species
Mus musculus
Symbol
Nedd4
Name
neural precursor cell expressed, developmentally down-regulated 4
Synonyms
  • AA959633
  • AL023035
Biotype
protein coding gene
Automated Description
Enables several functions, including ionotropic glutamate receptor binding activity; proline-rich region binding activity; and protein phosphorylated amino acid binding activity. Involved in negative regulation of vascular endothelial growth factor receptor signaling pathway and regulation of dendrite morphogenesis. Acts upstream of or within several processes, including circulatory system development; protein monoubiquitination; and regulation of primary metabolic process. Located in cytosol and membrane. Part of ubiquitin ligase complex. Is active in glutamatergic synapse and postsynaptic cytosol. Is expressed in several structures, including alimentary system; eye; genitourinary system; limb; and nervous system. Orthologous to human NEDD4 (NEDD4 E3 ubiquitin protein ligase).
MGI Description
PHENOTYPE: Homozygous mutation of this gene results in neonatal lethality and heterozygous mice have decreased body weights. Mice homozygous for a knockout allele exhibit impaired neurite development. Mice homozygous for a gene trapped allele on a B6 congenic background exhibit male to female sex reversal and lethality through fetal development. [provided by MGI curators]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR11254
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
GRCm39
Viewer Help
72.57M72.58M72.59M72.60M72.61M72.62M72.63M72.64M72.65M

Sequence Details

Loading...

Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions