Version: 8.0.0Date: Tue Jan 28 2025
Gene
Mycn
- Species
- Mus musculus
- Symbol
- Mycn
- Name
- v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived
- Synonyms
- bHLHe37
- N-myc
- Biotype
- protein coding gene
- Automated Description
- Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and kinase binding activity. Involved in negative regulation of reactive oxygen species metabolic process and positive regulation of transcription by RNA polymerase II. Acts upstream of with a positive effect on autosome genomic imprinting. Acts upstream of or within several processes, including negative regulation of astrocyte differentiation; positive regulation of cell population proliferation; and skeletal system morphogenesis. Located in nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; lung; and sensory organ. Human ortholog(s) of this gene implicated in Feingold syndrome. Orthologous to human MYCN (MYCN proto-oncogene, bHLH transcription factor).
- MGI Description
- PHENOTYPE: Homozygotes for targeted null mutations exhibit impaired development of the mesonephric tubules, neuroepithelium, sensory ganglia, heart, lung, stomach, and liver. Mutants die around embryonic day 11.5. [provided by MGI curators]
- Cross References
- Additional Information
- Literature
Orthology
- Gene tree
- PANTHER:PTHR45851
Links to orthology data in JBrowse by filter level: Stringent, Moderate, No filter, Best and Best Reverse
Disease Associations
Cases where the expected disease association was NOT found
Cell color indicative of annotation volume
Sequence Feature Viewer
- Genome location
- Chr12:12986094...12991837 - (5.74 kb)
- Assembly version
- GRCm39
- Viewer Help
Data currently unavailable; sequence viewer under construction