Gene

Nos2

Species
Mus musculus
Symbol
Nos2
Name
nitric oxide synthase 2, inducible
Synonyms
  • iNos
  • iNOS
Biotype
protein coding gene
Automated Description
Enables several functions, including anion binding activity; heme binding activity; and nitric-oxide synthase activity. Involved in several processes, including negative regulation of macromolecule metabolic process; nitric oxide biosynthetic process; and peptidyl-cysteine S-nitrosylation. Acts upstream of or within several processes, including cellular response to type II interferon; response to bacterium; and superoxide metabolic process. Located in cortical cytoskeleton and perinuclear region of cytoplasm. Is expressed in several structures, including alimentary system; brain; enteric nervous system; extraembryonic component; and genitourinary system. Used to study Alzheimer's disease and type 1 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including dementia (multiple); hypertension (multiple); malaria; pulmonary tuberculosis; and type 2 diabetes mellitus. Orthologous to human NOS2 (nitric oxide synthase 2).
MGI Description
PHENOTYPE: Homozygous deletion of this gene alters susceptibility to infection, response to injury, sepsis and sensory stimuli, cardiac function, osteoclast, platelet and mammary gland physiology, tumor growth, testis and uterus morphology, diet-induced atherosclerosis, and blood, urine and glucose metabolism. [provided by MGI curators]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR19384
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

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Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
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    Alleles and Variants

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      Transgenic Alleles

      Species
      (carrying the transgene)
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        Models

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          Sequence Feature Viewer

          Genome location
          Assembly version
          GRCm39
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          Sequence Details

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          Expression

          Primary Sources
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          Nos2 molecule type
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            Genetic Interactions

            Nos2 role
            Nos2 genetic perturbation
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