Gene

Ntf3

Species
Mus musculus
Symbol
Ntf3
Name
neurotrophin 3
Synonyms
  • AI316846
  • AI835689
Biotype
protein coding gene
Automated Description
Predicted to enable nerve growth factor binding activity; nerve growth factor receptor binding activity; and receptor ligand activity. Acts upstream of or within several processes, including nervous system development; neuromuscular synaptic transmission; and positive regulation of transcription by RNA polymerase II. Located in cytoplasmic vesicle. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Used to study atrial heart septal defect 1 and tetralogy of Fallot. Human ortholog(s) of this gene implicated in Alzheimer's disease and asthma. Orthologous to human NTF3 (neurotrophin 3).
MGI Description
PHENOTYPE: Homozygotes for targeted null mutations exhibit loss of peripheral sensory and sympathetic neurons, lack of spinal propioceptive afferents and their sense organs, impaired suckling and movement, and postnatal lethality. Heterozygotes show mild defects. [provided by MGI curators]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR11589
No data available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

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    Disease Associations

    Cases where the expected disease association was NOT found
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      Alleles and Variants

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        Transgenic Alleles

        Species
        (carrying the transgene)
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          Models

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            Sequence Feature Viewer

            Genome location
            Assembly version
            GRCm39
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            126.08M126.09M126.10M126.11M126.12M126.13M126.14M

            Sequence Details

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            Expression

            Primary Sources
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            Ntf3 molecule type
            Interactor gene
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              Genetic Interactions

              Ntf3 role
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