Gene

Pcna

Species
Mus musculus
Symbol
Pcna
Name
proliferating cell nuclear antigen
Synonyms
  • Pcna/cyclin
  • PCNAR
Biotype
protein coding gene
Automated Description
Enables enzyme binding activity. Involved in mitotic telomere maintenance via semi-conservative replication and replication fork processing. Acts upstream of or within base-excision repair, gap-filling; cellular response to xenobiotic stimulus; and negative regulation of transcription by RNA polymerase II. Located in male germ cell nucleus; nuclear lamina; and replication fork. Part of cyclin-dependent protein kinase holoenzyme complex. Is expressed in several structures, including brain; genitourinary system; jaw; musculoskeletal system; and sensory organ. Human ortholog(s) of this gene implicated in ataxia-telangiectasia-like disorder-2. Orthologous to human PCNA (proliferating cell nuclear antigen).
MGI Description
PHENOTYPE: Mice homozygous for a knock-out allele exhibit complete embryonic lethality before implantation due to defects in DNA replication. Mice homozygous for a knock-in allele show partial embryonic lethality during organogenesis, absent germ cells, infertility, and altered somatic hypermutation frequency. [provided by MGI curators]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR11352
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
GRCm39
Viewer Help
132.0915M132.0920M132.0925M132.0930M132.0935M132.0940M132.0945M132.0950M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions