Gene

Pdgfa

Species
Mus musculus
Symbol
Pdgfa
Name
platelet derived growth factor, alpha
Synonyms
  • PDGFACP
Biotype
protein coding gene
Automated Description
Predicted to enable several functions, including platelet-derived growth factor binding activity; protein dimerization activity; and signaling receptor binding activity. Involved in digestive tract development; embryonic lung development; and lung alveolus development. Acts upstream of or within several processes, including hair follicle development; positive regulation of mesenchymal cell proliferation; and regulation of branching involved in salivary gland morphogenesis by epithelial-mesenchymal signaling. Located in extracellular space and microvillus. Is expressed in several structures, including alimentary system; extraembryonic component; genitourinary system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in high grade glioma. Orthologous to human PDGFA (platelet derived growth factor subunit A).
MGI Description
PHENOTYPE: Homozygotes for a targeted null mutation die either before E10.0 or postnatally. The latter exhibit lung emphysema, reduced numbers of oligodendrocytes, tremors, and abnormalities of the skin, hair follicles, and gastrointestinal lining. [provided by MGI curators]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR11633
No data available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
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Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
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      Alleles and Variants

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      Variant type
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        Transgenic Alleles

        Species
        (carrying the transgene)
        Allele symbol
        Transgenic construct
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        Knock-down targets
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          Models

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            Sequence Feature Viewer

            Genome location
            Assembly version
            GRCm39
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            138.962M138.964M138.966M138.968M138.970M138.972M138.974M138.976M138.978M138.980M138.982M

            Sequence Details

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            Expression

            Primary Sources
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            Pdgfa molecule type
            Interactor gene
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              Genetic Interactions

              Pdgfa role
              Pdgfa genetic perturbation
              Interactor gene
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