Version: 8.0.0
Date: Tue Jan 28 2025
Prkacb
Mus musculusMGI:97594
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

Prkacb

Species
Mus musculus
Symbol
Prkacb
Name
protein kinase, cAMP dependent, catalytic, beta
Synonyms
  • cAMP-dependent protein kinase C beta
  • Pkacb
Biotype
protein coding gene
Automated Description
Enables ATP binding activity; cAMP-dependent protein kinase activity; and magnesium ion binding activity. Involved in protein phosphorylation. Acts upstream of or within negative regulation of smoothened signaling pathway; neural tube closure; and regulation of protein processing. Located in ciliary base. Is expressed in several structures, including alimentary system; genitourinary system; hemolymphoid system gland; liver and biliary system; and nervous system. Orthologous to human PRKACB (protein kinase cAMP-activated catalytic subunit beta).
MGI Description
PHENOTYPE: Homozygotes for a targeted null mutation eliminating the Cbeta1 subunit exhibit impaired hippocampal plasticity, including failure of low frequency stimulation to produce lasting depression and the elimination of mossy fiber long term potentiation. [provided by MGI curators]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR24353
No data available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    Gene
    Association
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    Disease
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      Alleles and Variants

      Allele/Variant Symbol
      Allele Synonyms
      Category
      Variant
      Variant type
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        Transgenic Alleles

        Species
        (carrying the transgene)
        Allele symbol
        Transgenic construct
        Expressed components
        Knock-down targets
        Regulatory regions
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          Models

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            Sequence Feature Viewer

            Genome location
            Assembly version
            GRCm39
            Viewer Help
            146.44M146.45M146.46M146.47M146.48M146.49M146.50M146.51M

            Sequence Details

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            Expression

            Primary Sources
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            Prkacb molecule type
            Interactor gene
            Interactor species
            Interactor molecule type
            Detection methods
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              Genetic Interactions

              Prkacb role
              Prkacb genetic perturbation
              Interactor gene
              Interactor species
              Interactor role
              Interactor genetic perturbation
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