Gene

Ppia

Species
Mus musculus
Symbol
Ppia
Name
peptidylprolyl isomerase A
Synonyms
  • Cphn
  • CYCA
Biotype
protein coding gene
Automated Description
Enables integrin binding activity and peptidyl-prolyl cis-trans isomerase activity. Involved in platelet aggregation. Acts upstream of or within neuron differentiation. Located in extracellular space. Is expressed in several structures, including early conceptus; gonad; hemolymphoid system gland; liver; and skeletal muscle. Human ortholog(s) of this gene implicated in cholangiocarcinoma and human immunodeficiency virus infectious disease. Orthologous to human PPIA (peptidylprolyl isomerase A).
MGI Description
PHENOTYPE: Mice homozygous for disruptions in this gene tend to develop blepharitis (about 30% of mice) as well as inflammation in other organs. Some background dependent embryonic lethality occurs but adults are robust and live normal life spans. [provided by MGI curators]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR11071
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
GRCm39
Viewer Help
6.3660M6.3665M6.3670M6.3675M6.3680M6.3685M6.3690M6.3695M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions