Gene

Ptprz1

Species
Mus musculus
Symbol
Ptprz1
Name
protein tyrosine phosphatase receptor type Z, polypeptide 1
Synonyms
  • AI850339
  • DSD-1-PG
Biotype
protein coding gene
Automated Description
Enables protein tyrosine phosphatase activity. Involved in several processes, including oligodendrocyte differentiation; peptidyl-tyrosine dephosphorylation; and regulation of myelination. Acts upstream of or within axonogenesis and hematopoietic progenitor cell differentiation. Located in perineuronal net and plasma membrane. Is active in synapse. Is expressed in several structures, including central nervous system; cranial nerve; eye; genitourinary system; and limb. Orthologous to human PTPRZ1 (protein tyrosine phosphatase receptor type Z1).
MGI Description
PHENOTYPE: Mice homozygous for targeted null mutations demonstrate an impaired ability to recover from inflamatory lesions of the CNS or gastric mucosa. Mice homozygous for a knock-out allele exhibit increased tactile and thermal nociception thresholds. [provided by MGI curators]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR19134
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
GRCm39
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22.88M22.90M22.92M22.94M22.96M22.98M23.00M23.02M23.04M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions