Gene

Saa3

Species
Mus musculus
Symbol
Saa3
Name
serum amyloid A 3
Synonyms
  • AV098916
  • expressed sequence AV098916
Biotype
protein coding gene
Automated Description
Enables Toll-like receptor 4 binding activity and chemoattractant activity. Involved in response to stilbenoid. Acts upstream of or within several processes, including I-kappaB phosphorylation; cell chemotaxis; and cellular response to interleukin-1. Located in extracellular space. Is expressed in several structures, including cerebellum; ileum; liver; reproductive system; and thymus. Orthologous to human SAA3P (serum amyloid A3, pseudogene).
MGI Description
PHENOTYPE: Two chemically induced mutations result in prenatal lethality in homozygous mice. Mice homozygous for a knock-out allele exhibit reduced susceptibility to diet-induced obesity with improved lipid metabolism. [provided by MGI curators]
Cross References
Additional Information
Literature

Orthology

Gene tree
Not Available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
GRCm39
Viewer Help
46.3615M46.3620M46.3625M46.3630M46.3635M46.3640M46.3645M46.3650M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions