Gene

Shb

Species
Mus musculus
Symbol
Shb
Name
src homology 2 domain-containing transforming protein B
Synonyms
  • BC028832
  • cDNA sequence BC028832
Biotype
protein coding gene
Automated Description
Enables signaling receptor complex adaptor activity. Acts upstream of or within several processes, including hematopoietic stem cell proliferation; negative regulation of oocyte maturation; and positive regulation of immune response. Predicted to be located in cytoplasmic ribonucleoprotein granule; cytosol; and nucleoplasm. Is expressed in brain; molar; and sensory organ. Orthologous to human SHB (SH2 domain containing adaptor protein B).
MGI Description
PHENOTYPE: Mice homozygous for a null allele exhibit some embryonic lethality associated with various embryogenesis defects including loss of embryo structures, open neural tube, hemorrhaging and tail defects. Heterozygous mice exhibit a distortion in the transmission ratio of the allele maternally. [provided by MGI curators]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR15127
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
GRCm39
Viewer Help
45.43M45.44M45.45M45.46M45.47M45.48M45.49M45.50M45.51M45.52M45.53M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions