Gene

Tcf4

Species
Mus musculus
Symbol
Tcf4
Name
transcription factor 4
Synonyms
  • 5730422P05Rik
  • ASP-I2
Biotype
protein coding gene
Automated Description
Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; E-box binding activity; and TFIIB-class transcription factor binding activity. Involved in positive regulation of neuron differentiation; positive regulation of transcription by RNA polymerase II; and protein-DNA complex assembly. Acts upstream of or within several processes, including endothelial cell activation; negative regulation of macromolecule biosynthetic process; and regulation of vascular endothelial growth factor signaling pathway. Located in nucleus. Part of transcription regulator complex. Is expressed in several structures, including alimentary system; brain; genitourinary system; integumental system; and sensory organ. Used to study Pitt-Hopkins syndrome and schizophrenia. Human ortholog(s) of this gene implicated in Fuchs' endothelial dystrophy; Lynch syndrome; and Pitt-Hopkins syndrome. Orthologous to human TCF4 (transcription factor 4).
MGI Description
PHENOTYPE: Homozygotes for a null allele show a partial block in early thymopoiesis, increased double-negative T cell count, and increased sensitivity to anti-CD3 induced apoptosis. Homozygotes for another null allele show neonatal or postnatal lethality, reduced pro-B cell number, and abnormal pontine nuclei. [provided by MGI curators]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR11793
Stringency:
Additional filters to further constrain the results:
Species Gene symbol Count Best Best reverse
Method
Ensembl ComparaHGNCHieranoidInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidXenbaseZFIN
Homo sapiensTCF410 of 10YesYes  
Rattus norvegicusTcf49 of 9YesYes   
Xenopus tropicalistcf45 of 9YesYes   
Danio reriotcf41 of 10YesYes  
Drosophila melanogasterda8 of 9YesYes   
Caenorhabditis eleganshlh-25 of 9YesYes   
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Gene symbolRank Alignment Length (aa) Similarity %Identity %Method Count
Method
Ensembl ComparaHGNCInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidSGD
Tcf12171774617 of 9 
Tcf3269865497 of 9 

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
Phenotype Term
Annotation details
References
abnormal action potential
abnormal associative learning
abnormal B cell differentiation
abnormal brain development
abnormal brain morphology
abnormal corpus callosum morphology
abnormal dentate gyrus morphology
abnormal gait
abnormal habituation to a new environment
abnormal long-term spatial reference memory
Showing 1 - 10 of 45 rows
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Disease Associations

Cases where the expected disease association was NOT found
Must provide at least one subject
Cell color indicative of annotation volume

Transgenic Alleles

Species
(carrying the transgene)
Allele symbol
Transgenic construct
Expressed components
Knock-down targets
Regulatory regions
Has Disease Annotations
Has Phenotype Annotations
Mus musculusTg(Thy1-Tcf4)1Mjro
YesYes
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Models

Model name
Experimental condition
Associated Human Diseases
Associated Phenotypes
Modifier
Source
Tcf4em1Bdph/? [background:] involves: C57BL/6 * C57BL/6J
  • abnormal action potential
  • abnormal brain morphology
MGI
Tcf4em2Bdph/? [background:] involves: C57BL/6 * C57BL/6J
  • abnormal brain morphology
  • decreased brain weight
MGI
Tcf4tm1a(EUCOMM)Wtsi/Tcf4+ [background:] involves: C57BL/6N
  • abnormal corpus callosum morphology
  • abnormal dentate gyrus morphology
MGI
Tcf4tm1Hmb/Tcf4+ Tg(Nes-cre)1Kln/0 [background:] involves: 129P2/OlaHsd * C57BL/6 * SJL
  • abnormal brain morphology
  • decreased body weight
MGI
Tcf4tm1Hmb/Tcf4+ Tmem163Tg(ACTB-cre)2Mrt/Tmem163+ [background:] involves: 129P2/OlaHsd * C57BL/6 * FVB/N
  • abnormal habituation to a new environment
  • decreased anxiety-related response
MGI
Tcf4tm1Zhu/Tcf4+ [background:] involves: 129P2/OlaHsd * 129S1/SvImJ * C57BL/6J
  • abnormal gait
  • abnormal long-term spatial reference memory
MGI
Atoh1tm2Hzo/Atoh1+ Tcf4tm1Zhu/Tcf4+ [background:] involves: 129P2/OlaHsd
  • abnormal brain development
  • abnormal neuronal migration
MGI
Tcf12tm1Zhu/Tcf12+ Tcf4tm1Zhu/Tcf4+ [background:] involves: 129P2/OlaHsd * 129S7/SvEvBrd
  • decreased pro-B cell number
  • postnatal growth retardation
MGI
Tcf4tm1.1Hmb/Tcf4+ [background:] involves: 129P2/OlaHsd * C57BL/6J
  • increased double-negative T cell number
MGI
Tcf4tm1.1Hmb/Tcf4tm1.1Hmb [background:] involves: 129P2/OlaHsd * C57BL/6J
  • abnormal T cell differentiation
  • abnormal T cell physiology
MGI
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Sequence Feature Viewer

Genome location
Assembly version
GRCm39
Viewer Help
69.50M69.55M69.60M69.65M69.70M69.75M69.80M

Sequence Details

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Expression

Primary Sources
Other Sources
Must provide at least one subject
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

27 interactor genes based on 42 annotations
Tcf4 molecule type
Interactor gene
Interactor species
Interactor molecule type
Detection methods
Source
Reference
protein
ASCL3Homo sapiens
protein
  • two hybrid
PMID:11784080
protein
Ascl3Mus musculus
protein
  • two hybrid
PMID:11784080
protein
atoDrosophila melanogaster
protein
  • two hybrid
PMID:17878293
protein
atoDrosophila melanogaster
protein
  • two hybrid
PMID:17878293
protein
Atoh1Mus musculus
protein
  • anti tag coimmunoprecipitation
PMID:17878293
protein
Atoh1Mus musculus
protein
  • anti tag coimmunoprecipitation
PMID:17878293
protein
Cbfa2t3Mus musculus
protein
  • anti bait coimmunoprecipitation
PMID:16407974
protein
Cbfa2t3Mus musculus
protein
  • anti bait coimmunoprecipitation
PMID:16407974
protein
CCNFHomo sapiens
protein
  • affinity chromatography technology
PMID:36114006
protein
Ctnnb1Mus musculus
protein
  • affinity chromatography technology
PMID:15578569
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Genetic Interactions

Tcf4 role
Tcf4 genetic perturbation
Interactor gene
Interactor species
Interactor role
Interactor genetic perturbation
Interaction type
Phenotype or trait
Source
Reference
suppressor gene
Ctnnb1Mus musculus
suppressed gene
phenotypic suppression (sensu BioGRID)
  • abnormal intercellular signaling peptide or protein level, partial rescue
PMID:16478791
suppressor gene
HrasMus musculus
suppressed gene
phenotypic suppression (sensu BioGRID)
  • abnormal intercellular signaling peptide or protein level, partial rescue
PMID:16478791
suppressor gene
Wnt11Mus musculus
suppressed gene
phenotypic suppression (sensu BioGRID)
  • abnormal protein level, partial rescue
  • abnormal bone mineralization, partial rescue
PMID:19213727
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