Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including canonical Wnt signaling pathway involved in negative regulation of apoptotic process; gamma-delta T cell differentiation; and regulation of gamma-delta T cell differentiation. Acts upstream of or within several processes, including T cell differentiation; embryonic morphogenesis; and neural tube development. Located in euchromatin and nucleus. Is expressed in several structures, including alimentary system; branchial arch; central nervous system; genitourinary system; and sensory organ. Orthologous to human TCF7 (transcription factor 7).
MGI Description
PHENOTYPE: Homozygous null mice have defects in T cell development leading to decreased numbers of T cells in the periphery. [provided by MGI curators]