Gene

Tcf7

Species
Mus musculus
Symbol
Tcf7
Name
transcription factor 7, T cell specific
Synonyms
  • AI465550
  • expressed sequence AI465550
Biotype
protein coding gene
Automated Description
Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including canonical Wnt signaling pathway involved in negative regulation of apoptotic process; gamma-delta T cell differentiation; and regulation of gamma-delta T cell differentiation. Acts upstream of or within several processes, including T cell differentiation; embryonic morphogenesis; and neural tube development. Located in euchromatin and nucleus. Is expressed in several structures, including alimentary system; branchial arch; central nervous system; genitourinary system; and sensory organ. Orthologous to human TCF7 (transcription factor 7).
MGI Description
PHENOTYPE: Homozygous null mice have defects in T cell development leading to decreased numbers of T cells in the periphery. [provided by MGI curators]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR10373
No data available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume
Gene
Association
Disease Qualifier
Disease
Evidence
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    Transgenic Alleles

    Models

    Sequence Feature Viewer

    Genome location
    Assembly version
    GRCm39
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    52.145M52.150M52.155M52.160M52.165M52.170M

    Sequence Details

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    Expression

    Primary Sources
    Other Sources
    Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

    Molecular Interactions

    Genetic Interactions